Review Hepatotoxicity of molecular targeted therapy

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Hepatotoxicity of molecular targeted therapy

A constant increase in occurrence of neoplasms is observed; hence new methods of therapy are being intensively researched. One of the methods of antineoplastic treatment is molecular targeted therapy, which aims to influence individual processes occurring in cells. Using this type of medications is associated with unwanted effects resulting from the treatment. Liver damage is a major adverse ef...

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The HER family of receptor tyrosine kinases, including EGF receptor (EGFR), HER2, HER3, and HER4, transduce growth-promoting signals in response to ligand binding to their extracellular domains (ECD). This family is deregulated in numerous cancers, with mutations in EGFR and HER2 often serving as "driver" events to activate key growth factor signaling pathways such as the RAS-ERK and PI3K-AKT p...

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ژورنال

عنوان ژورنال: Współczesna Onkologia

سال: 2015

ISSN: 1428-2526

DOI: 10.5114/wo.2014.43495